Once you have been diagnosed with a low testosterone condition, what can you do about it? To many, the obvious choice would seem to be testosterone replacement therapy, or TRT. This type of treatment is administered by a physician, and may take many forms. You could use patches, which can irritate the skin, or creams, which must be carefully protected from touch by others. It could also entail a patch on your gum, which could be irritating, implants under the skin of your buttocks, or periodic injections.